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KMID : 0363620060270020070
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 2 p.70 ~ p.85
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Neuroprotective Effect of HyulBuChookAu-Tang on Focal Cerebral Ischemia of the Rats
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Cho Eun-Hee
Kwon Jung-Nam
Kim Young-Gyun
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Abstract
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Objectives:This study examined the neuroprotective effect of Hyulbuchookautang (血府逐瘀湯, HBCAT)against neural damage following focal cerebral infarction.
Methods:Sprague-Dawley Rats were induced with focal cerebral infarction by temporal middle cerebral artery occlusion (MCAO). The rats were divided into 2 groups. We treated extract of HBCAT to one group after operation (sample group), and the other group wasn’’t treated after operation (control group). We observed neurological scores and TIC-stained infarct area, total infarct volume in brain sections and Bax-positive neurons, HSP70- positive neurons in brain regions.
Results:HBCAT treatment at 3 days after MCAO reduced neurological scores induced by MCAO. HBCAT treatment at 5 days after MCAO reduced TTC-stained infarct area in brain sections induced by MCAO. HBCAT treatment at 5 days after MCAO reduced total infarct volume in brain sections induced by MCAO. HBCAT treatment after MCAO reduced Bax-positive neurons in cortex infarct core and cortex infarct penumbra and caudo-putamen of brain regions induced by MCAO. HBCAT treatment after MCAO reduced HSP70- positive neurons in cortex infarct penumbra of brain regions induced by MCAO.
Conclusions: These results suggest that HBCAT has a neuroprotective effect against focal cerebral ischemia.
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KEYWORD
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Hyulbuchookautang(血府逐瘀湯, HBCAT), middle cerebral artery occlusion(MCAO), neuroprotective effect, focal cerebral infarction
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